The present study investigates the way infants express their emotions in relation to parental feelings between maternal and paternal questions and direct requests. We therefore compared interpersonal engagement accompanying parental questions and direct requests between infant–mother and infant–father interactions. We video-recorded spontaneous communication between 11 infant–mother and 11 infant–father dyads—from the 2nd to the 6th month—in their home. The main results of this study are summarized as follows: (a) there aresimilaritiesin the way preverbal infants use their affections in spontaneous interactions (...) with their mothers and fathers to express signs of sensitivity in sharing knowledge through questions and direct requests; and (b) the developmental trajectories of face-to-face emotional coordination in the course of parental questions descend in a similar way for both parents across the age range of this study. Regarding the developmental trajectories of emotional non-coordination, there is evidence of a linear trend in terms of age difference between the parents’ gender with fathers showing the steeper slope. The results are discussed in relation to the theory of intersubjectivity. (shrink)

Until recently, cardiotoxicity in the setting of a malignant disease was attributed solely to the detrimental effects of chemo‐ and/or radio‐therapy to the heart. On this account, the focus was on the evaluation of well‐established cardiac biomarkers for the early detection of myocardial damage. Currently, this view has been revised. Cardiotoxicity is not restricted to a single organ but instead affects the endothelium as a whole. Indeed, it has come into light that not only cancer therapy but also malignant cells (...) per se can impair the cardiovascular system, through a paracrine and endocrine mode of action. Even more intriguingly, a clear interplay between molecular pathways involved in cancer and cardiovascular disease has become prevalent, suggesting a common nominator that governs the pathophysiology of these two entities. Taken together, our strategy in the quest of novel biomarkers in the emerging field of cardio‐oncology should be critically reshaped. (shrink)

BackgroundThe Asclepion of Epidaurus is one of the first healing environments in the world. Descendants of Asclepius, specifically medical students, have been singularly deprived of any information concerning this legacy. This article illuminates the role of Asclepion of Epidaurus and examines the view of medical students upon the subject and the possible benefits of this knowledge in their medical education.MethodsThe participants were 105 senior-year students from the Athens Medical School, who attended a multi-media assisted lecture related to the structure and (...) the role of the Asclepion of Epidaurus. Afterwards, they answered anonymously a questionnaire of 12 pairs of opposite adjectives in order to describe their view regarding the meaning of Asclepion. The method used in the evaluation of their answers was that of semantic differential.ResultsThe attitude of the students towards the meaning of Asclepion was positive, showing interest and excitement about a powerful, though unfamiliar piece of knowledge.ConclusionToday’s novice doctors have welcomed the concept of Asclepion as essential knowledge for the service they will be called to fulfill. The potential benefits of the Asclepian ideals in medical education and ethos are thoroughly discussed. (shrink)

This book traces the intellectual revolution initiated by Thales in the sixth century BC to its culmination in the metaphysics of Parmenides.

Context Physicians are regularly confronted with research that is funded or presented by industry. Objective To assess whether physicians discount for conflicts of interest when weighing evidence for prescribing a new drug. Design and setting Participants were presented with an abstract from a single clinical trial finding positive results for a fictitious new drug. Physicians were randomly assigned one version of a hypothetical scenario, which varied on conflict of interest: ‘presenter conflict’, ‘researcher conflict’ and ‘no conflict’. Participants 515 randomly selected (...) Fellows in the American College of Obstetricians and Gynecologists' Collaborative Ambulatory Research Network; 253 surveys (49%) were returned. Main object measures The self-reported likelihood that physicians would prescribe the new drug as a first-line therapy. Results Physicians do not significantly discount for conflicts of interest in their self-reported likelihood of prescribing the new drug after reading the single abstract and scenario. However, when asked explicitly to compare conflict and no conflict, 69% report that they would discount for researcher conflict and 57% report that they would discount for presenter conflict. When asked to guess how favourable the results of this study were towards the new drug, compared with the other trials published so far, their perceptions were not significantly influenced by conflict of interest information. Conclusion While physicians believe that they should discount the value of information from conflicted sources, they did not do so in the absence of a direct comparison between two studies. This brings into question the effectiveness of merely disclosing the funding sources of published studies. (shrink)

The Fourth Edition of this bestselling, highly regarded book has been fully revised to incorporate changes in law and clinical guidance making a vital impact on patient management, encompassing: The Equalities Act 2010 which provides a right of older people to treatment without discrimination ; Case law on withdrawing nutrition and hydration ; Updated guidance on resuscitation from the Resuscitation Council, the British Medical Association and the Royal College of Nursing ; The redefining of good medical practice by the General (...) Medical Council ; The abolition of the Liverpool Care Pathway with an updated guidance on end of life care and advance care planning. Expanded throughout, this new edition also integrates two entirely new chapters covering testamentary capacity and role of the physician, and religious beliefs and end of life issues. Its practical, reflective and informative approach continue to make it essential reading for all health professionals, particularly trainees, involved in making difficult decisions in the care of older persons. It is also highly recommended for undergraduate medical students. (shrink)

Open peer commentary on the article “The Banathy Conversation Methodology” by Gordon Dyer, Jed Jones, Gordon Rowland & Silvia Zweifel. Upshot: This commentary will address the implicit and explicit connections between Banathy’s Conversation Methodology, which is the heart of the process used at the IFSR Conversations held every two years in Austria, and constructivist theories in application.

The faults of logical empiricist accounts of metascientific discourse are examined through a study of the modifications Carnap makes to his version of the program over four decades. As empiricists acquiesced on the distinction between theory and observation, Carnap attempted to retain and insulate an equally suspect sharp distinction between the theoretic and the pragmatic. Carnap's later philosophy was understood as a modification of the program in the direction of pragmatism. But neither the key notion of "external questions" nor an (...) instrumentalist understanding of "pragmatic utility" are genuinely compatible with pragmatism. This underlines the need to clarify what is unique to pragmatic views of cognitive evaluation and normative discourse as they affect scientific reasoning. I conclude by suggesting how pragmatic conceptions of metascientific discourse can work to correct misconceptions about norm generation and governance that are shared in logicist and historicist accounts. (shrink)

A Finslerian extension of general relativity is examined with particular emphasis on the Finslerian generalization of the equation of motion in a gravitational field. The construction of a gravitational Lagrangian density by substituting the osculating Riemannian metric tensor in the Einstein density is studied. Attention is drawn to an interesting possibility for developing the theory of test bodies against the Finslerian background.

The analysis of a previous paper (see Ref. 1), in which the possibility of a Finslerian generalization of the equations of motion of gravitational field sources was demonstrated, is extended by developing the Finslerian generalization of the gravitational field equations on the basis of the complete contractionK = K lj lj of the Finslerian curvature tensorK l j hk (x, y). The relevant Lagrangian is constructed by the replacement of the directional variabley i inK by a vector fieldy i (x), (...) so that the notion of osculation may be regarded as the key concept on which the approach is based. The introduction of the auxiliary vector fieldy i (x) is shown to be of physical significance, for the field equations refer not only to the proper field variables but also to a special coordinate system associated withy i (x) through the Clebsch representation of the latter. The status of the conservation laws proves to be similar to that in the theory of the Yang-Mills field. By choosing a special Finslerian metric function we elucidate in detail the structure of the field equations in the static case. (shrink)

Professor Peter Bodunrin's paper ‘The Question of African Philosophy’ 161–179) has, as it were, become the first question for most African scholars, teachers or students, starting a course in African philosophy. In most of the discussions, the controversy over what constitutes an African philosophy tends to dominate, sometimes so much that it forms almost the entire content of the course.

Informed Christians have learned in our day that Islâm is not a primitive desert religion spread by the sword, for which faith is reduced to fatalism and women have no souls. Yet Christian historians of religion who avoid such gross errors still tend to present Islâm as at best an imperfect and parochial version of Christian truth, lacking any distinctive genius truly worthy of its independent dignity among the world religions. But until modern times, when the Christianity (and Judaism) of (...) Europeans has been radically transformed along with their secular life, Christianity must long have struck an observer from Mars as, compared to Islâm, the relatively localized faith of largely backward lands. Islâm was the vehicle of a complex and sophisticated sense of social order in a varied and highly creative civilization which was expanding continuously until its field of action encompassed half mankind; it was the only one of the major historical religions which had successfully displaced in large areas other major faiths such as Christianity, Hinduism, and Buddhism. The Martian observing human history in the later Middle Ages might find it easier to understand why Muslims have looked on Christianity as merely an abortive form of Islâm, as for instance in the approach of those Şûfîs, Muslim mystics, who see the perfection of Islâm in its uniting at once the dispensation of Law, which reflects the Majesty of God, and the dispensation of Grace, which reflects his Beauty, whereas Judaism and Christianity are limited to only the one or the other. This Muslim conception is as inadequate, however, as its Christian counterpart. Probably any widespread religious system will find a place for all major types of religious insight and practice and is in its own way complete. Yet, as each system has matured, it has revealed a characteristic persistent pattern of norms in the interrelation and subordination to one another of all the elements embodied in it. If Christians are to perceive the genius of Islâm, it must perhaps be through the comparison of such persistent patterns. (shrink)